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Ann N Y Acad Sci. 2000;909:41-50.

Peripheral opioid modulation of visceral pain.

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  • 1Department of Pharmacology, University of Iowa College of Medicine, Iowa City 52242-1109, USA.


Opioids are widely and successfully used for control of pain, including pain arising from the viscera. Constipating, sedating, respiratory depressant and other effects of opioids, however, often limit their long-term use in the treatment of a variety of visceral pain states. Accordingly, understanding visceral pain mechanisms and its modulation is important to developing improved strategies for pain control.

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