Format

Send to

Choose Destination
See comment in PubMed Commons below
Arch Fam Med. 2000 Jul;9(7):617-23.

Does influenza vaccination exacerbate asthma? Analysis of a large cohort of children with asthma. Vaccine Safety Datalink Team.

Author information

1
Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. pdk3@cdc.gov

Abstract

CONTEXT:

Although influenza vaccination is recommended for children with asthma, only a minority are vaccinated. One reason for low influenza vaccine coverage among children with asthma may be concern that influenza vaccination may induce an exacerbation of asthma.

OBJECTIVE:

To evaluate the safety of influenza vaccination in children with asthma, we studied the incidence of hospitalizations and emergency department visits for asthma following influenza vaccination.

DESIGN:

Retrospective cohort study-analysis of population-based computerized medical and vaccination records.

SETTING:

: Four large health maintenance organizations on the West Coast of the United States.

SUBJECTS:

Children with asthma 1 through 6 years of age, identified by search of computerized databases of medical encounters and pharmacy prescriptions.

MAIN OUTCOME MEASURES:

Exacerbations of asthma.

RESULTS:

In unadjusted analyses vaccination was associated with high rates of asthma exacerbations. However, after adjusting for asthma severity using a self-control method, the incidence rate ratios of asthma exacerbations after vaccination were 0.58 (95% confidence interval, 0.36-0.95), 0.74 (95% confidence interval, 0.47-1.17), and 0.98 (95% confidence interval, 0.76-1.27) during the 3 influenza seasons.

CONCLUSIONS:

After controlling for asthma severity, we found that influenza vaccination does not result in acute asthma exacerbations in children. Concern about possible exacerbation of asthma is not a valid reason to not vaccinate children with asthma against influenza.

PMID:
10910309
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center