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Hematol Oncol Clin North Am. 2000 Jun;14(3):641-57.

Serum tryptase and the laboratory diagnosis of systemic mastocytosis.

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Division of Rheumatology, Allergy, and Immunology, Virginia Commonwealth University, Richmond, USA.


Total tryptase levels of 20 ng/mL or higher in a baseline serum sample when the ratio of total to beta-tryptase is 20 or greater strongly suggest underlying systemic mastocytosis. Whether these criteria prove to be more sensitive than a bone marrow biopsy will require further study. Although the absolute level of total tryptase does not predict disease severity, it may provide a practical method for assessing the efficacy of therapeutic interventions designed to reduce the mast cell burden.

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