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J Card Fail. 2000 Jun;6(2):77-9.

Electrophysiological changes of angiotensin-converting enzyme inhibition after myocardial infarction.

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Thoraxcenter, Department of Cardiology, University Hospital Groningen, The Netherlands.


To investigate whether prevention of remodeling would translate into a more stable electrophysiological profile, the investigators randomized 56 patients to treatment with angiotensin-converting enzyme (ACE) inhibition or placebo for 3 months after myocardial infarction. Programmed electrical stimulation revealed no significant differences in inducibility of monomorphic sustained ventricular tachycardia (VT), whereas ventricular fibrillation (VF) tended to be lower in the ACE-inhibitor group. Effective refractory periods were consistently longer, and dispersion of refractoriness was significantly shorter in the ACE-inhibitor group. The investigators conclude that in this small patient group ACE inhibition may mildly add to a more stable electrophysiological profile.

[Indexed for MEDLINE]

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