Format

Send to

Choose Destination
See comment in PubMed Commons below
J Neural Transm (Vienna). 1999;106(7-8):757-61.

Piracetam reverses hippocampal membrane alterations in Alzheimer's disease.

Author information

  • 1Department of Pharmacology, Biocenter, University of Frankfurt, Federal Republic of Germany.

Abstract

The in vitro effects of piracetam treatment on the fluidity of membranes from the hippocampus of Alzheimer's Disease patients (AD) and non-demented controls were studied. Hippocampal membranes of AD patients showed a significant lower hydrocarbon core fluidity compared with membranes from elderly non-demented controls. Preincubation with piracetam enhanced the hydrocarbon core fluidity of hippocampal membranes from AD-patients as well as elderly controls in a concentration depending fashion, although the effect was more pronounced for the AD membranes. In the presence of piracetam, the difference of the membrane fluidity between AD and control membranes was not longer apparent.

PMID:
10907734
DOI:
10.1007/s007020050196
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center