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EXS. 1999;87:211-21.

Mammalian chitinase-like proteins.

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Département d'Obstétrique-Gynécologie, Centre Hospitalier de l'Université de Montréal, Hôpital Saint-Luc, Québec, Canada.


Mammals express genes coding for proteins that show significant similarity to chitinases of family 18 glycosyl hydrolases. These chitinase-like proteins have no chitinase activity due to changes in critical residues in the putative active center. One of these is oviductin, a high molecular weight glycoprotein most likely involved in fertilization and protection of the tubal epithelium owing to its mucin character. Another is YKL-40 (HCgp39) produced in association with tissue remodeling. Such proteins could have a general function in morphogenesis.

[Indexed for MEDLINE]

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