Format

Send to

Choose Destination
See comment in PubMed Commons below
Semin Cell Dev Biol. 2000 Jun;11(3):165-71.

Targeting of lysosomal proteins.

Author information

1
Institut de Biologie de Lille, CNRS EP525, Institut Pasteur de Lille, France.

Abstract

Proper cell homeostasis requires the efficient transport of a large variety of soluble acid hydrolases and transmembrane proteins from the trans-Golgi network (TGN) to lysosomes. While most of these molecules reach this degradative compartment, some transmembrane proteins, in particular, the acid hydrolase receptors are retrieved to the TGN. This bidirectional transport process involves the formation of several vesicular transport intermediates in which cargo molecules are selectively packaged. This review summarizes our current understanding of the molecular mechanisms leading to the proper targeting of lysosomal proteins.

PMID:
10906273
DOI:
10.1006/scdb.2000.0168
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center