Risk factors for microalbuminuria in children and adolescents with type 1 diabetes

J Pediatr Endocrinol Metab. 2000 Jun;13(6):613-20. doi: 10.1515/jpem.2000.13.6.613.

Abstract

Objectives: The aim of this study was to investigate the influence of sex, age, diabetes duration, puberty, blood pressure, glycemic control and parental blood pressure on microalbuminuria in children with type 1 diabetes.

Study design: The study was a multicenter cross-sectional survey including 702 children and adolescents (age = 14.3+/-2.9 yr) with type 1 diabetes duration of 7.6+/-3.1 yr. One third of the population had not undergone pubertal development. Blood pressure was measured in children and their parents using a Dinamap instrument. Microalbuminuria was defined as a urinary albumin excretion rate > or = 15 microg/min measured on at least two out of three urine collections. HbA1c centrally measured by HPLC, was 8.7+/-1.5%.

Results: The proportion of permanent microalbuminuria was 5.1+/-1.6%. The prevalence was significantly enhanced after 10 yr of diabetes duration (11.6+/-5.2%) and complete puberty (8.2+/-3.1%). Independent risk factors for microalbuminuria tested in a logistic regression model were diabetes duration (OR/1 yr = 1.04-1.32), complete puberty (OR = 5.02-8.0), and maternal hypertension (OR = 1.94-4.28). HbA1c had a borderline independent and significant effect (OR/1% = 0.96-1.62; p = 0.07).

Conclusions: Our results indicate that pubertal adolescents with a long duration of the disease and maternal history of hypertension are candidates for targeted interventions with the objective of reducing the rate of developing nephropathy in these individuals.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Albuminuria* / epidemiology
  • Albuminuria* / etiology
  • Blood Glucose / metabolism
  • Blood Pressure
  • Child
  • Cross-Sectional Studies
  • Diabetes Mellitus, Type 1 / urine*
  • Female
  • Glycated Hemoglobin / analysis
  • Humans
  • Male
  • Puberty
  • Risk Factors
  • Sex Characteristics
  • Time Factors

Substances

  • Blood Glucose
  • Glycated Hemoglobin A