Format

Send to

Choose Destination
Trends Genet. 2000 Aug;16(8):351-6.

NuRD and SIN3 histone deacetylase complexes in development.

Author information

1
Wellcome CRC Institute, Cambridge, UK. jaa@mole.bio.cam.ac.uk

Abstract

Transcription repression mediated through histone deacetylase (HDAC) complexes is widespread, and mechanisms by which HDAC complexes act have been revealed by extensive studies in vitro and in cell culture. However, until recently, little has been known about the developmental roles of histone deacetylation. Mutants now exist for a number of members of the two major HDAC complexes (NuRD and SIN3) and some associated proteins. The emerging picture is that these complexes have specific functions in development, rather than being required for most cellular processes.

PMID:
10904264
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center