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Immunopharmacology. 2000 Aug;49(1-2):103-16.

Functional domains, structural variations and pathogen interactions of MCP, DAF and CR1.

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Department of Medicine, Division of Rheumatology, Washington University School of Medicine, Saint Louis, MO 63110, USA.


The Regulators of Complement Activation (RCA) are a fascinating group of proteins that play important roles in innate and acquired immunity. In this review, we examine structure-function aspects of three membrane-bound RCA proteins and discuss the unique impact of their genetic organization on their evolution.

[Indexed for MEDLINE]

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