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Nat Neurosci. 2000 Aug;3(8):771-9.

SLO-2, a K+ channel with an unusual Cl- dependence.

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Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 South Euclid, Saint Louis, Missouri 63110, USA.


The gating of different potassium channels depends on many diverse factors. We now report a unique example of a K+ channel with a Cl - dependence. The slo-2 gene was cloned from Caenorhabditis elegans and is widely expressed in both neurons and muscles; it was highly abundant, as suggested by its high representation in the C. elegans EST database. SLO-2, like its paralogue, SLO-1, was also dependent on Ca 2+. We show by site-directed mutagenesis that its requirements for both Cl- and Ca2+ are synergistic and associated with the same functional domain. SLO-2's dependence on Cl - implies that intracellular Cl- homeostasis may be important in regulating cellular excitability through this unusual K+ channel.

[Indexed for MEDLINE]

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