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BJOG. 2000 Jul;107(7):870-6.

A pilot study of Hypericum perforatum for the treatment of premenstrual syndrome.

Author information

1
Department of Complementary Medicine, School of Postgraduate Medicine and Health Sciences, University of Exeter, UK.

Abstract

OBJECTIVE:

To investigate whether Hypericum perforatum could relieve symptoms of premenstrual syndrome in a small group of women in order to establish a hypothesis and to test methods for conducting a future randomised controlled trial.

DESIGN:

Prospective, open, uncontrolled, observational study.

SETTING:

Department of Complementary Medicine, University of Exeter.

POPULATION:

Nineteen women with premenstrual syndrome who were in otherwise good physical and mental health and not taking other treatments for premenstrual syndrome.

METHOD:

Volunteers underwent a preliminary screening interview, completed Daily Symptom Ratings for one cycle, and attended a medical screening visit before being diagnosed with premenstrual syndrome. Participants took hypericum tablets for two complete menstrual cycles (1 x 300 mg hypericum extract per day standardised to 900 microg hypericin).

MAIN OUTCOME MEASURES:

Symptoms were rated daily throughout the trial using a validated measure. The Hospital Anxiety and Depression scale and modified Social Adjustment Scale were administered at baseline and after one and two cycles of treatment.

RESULTS:

There were significant reductions in all outcome measures. The degree of improvement in overall premenstrual syndrome scores between baseline and the end of the trial was 51%, with over two-thirds of the sample demonstrating at least a 50% decrease in symptom severity. Tolerance and compliance with the treatment were encouraging.

CONCLUSION:

The results of this pilot study suggest that there is scope for conducting a randomised, placebo-controlled, double-blind trial to investigate the value of hypericum as a treatment for premenstrual syndrome.

PMID:
10901558
[Indexed for MEDLINE]
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