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Curr Opin Immunol. 2000 Aug;12(4):448-55.

Costimulation in antiviral immunity: differential requirements for CD4(+) and CD8(+) T cell responses.

Author information

1
Department of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA. jwhitmire@mail.liai.org

Abstract

A key step toward improving vaccines is understanding the molecular interactions responsible for inducing antiviral T cell responses. An emerging theme from recent studies is that CD4(+) and CD8(+) T cell responses require distinct costimulatory pathways for activation. In addition, these costimulatory interactions can play a crucial role during the death phase of the T cell response and determine the number of effector T cells that survive to become memory T cells.

PMID:
10899032
DOI:
10.1016/s0952-7915(00)00119-9
[Indexed for MEDLINE]

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