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Curr Opin Immunol. 2000 Aug;12(4):381-6.

The CD4(+) T cell response to HIV-1.

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Vaccine and Gene Therapy Institute, Oregon Health Sciences University, Mail Code L220, Portland, OR 97201-3098, USA.


Although virus-specific CD4(+) T cells have proven to be a critical component of the immunologic control of chronic viral infections in a number of models, the role and even the existence of HIV-1-specific CD4(+) T cells in human HIV-1 infection has been controversial. Recent advances in quantifying and functionally characterizing HIV-1-specific T cells may shed light on the participation of these cells in anti-HIV-1 host defense.

[Indexed for MEDLINE]

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