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Curr Opin Immunol. 2000 Aug;12(4):375-80.

The role of CD4(+) T helper cells in the cytotoxic T lymphocyte response to HIV-1.

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Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02114, USA.


Virus-specific CD4(+) T cell help and CD8(+) cytotoxic T cell (CTL) responses are critical for the maintenance of effective immunity in chronic viral infections. HIV-1 infection presents a unique situation in which HIV-1-specific T helper cell responses are characteristically impaired and virus-specific CTLs wane over time as disease progresses; a relationship exists between T cell help and CTL responses in HIV-1 infection.

[Indexed for MEDLINE]

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