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Methods Find Exp Clin Pharmacol. 2000 Apr;22(3):159-62.

Role of angiotensin-converting enzyme inhibitor, lisinopril, on spermatozoal functions in rats.

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Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.


Angiotensin-converting enzyme is present in the male reproductive system but its role in the physiology of reproduction is not known. To see the effect of angiotensin-converting enzyme on spermatozoal functions, lisinopril, an angiotensin-converting enzyme inhibitor, was administered orally using two different doses (10 and 20 mg/kg/day) to rats. Both short-term (2 weeks) and long-term (6 weeks) effects of the drug were observed. Lisinopril treatment resulted in a marked decrease in sperm density, sperm motility and zona pellucida penetration. Acrosome reaction by spermatozoa obtained from drug-treated animals was significantly lower when compared with spermatozoa from normal animals.

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