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Neurology. 2000 Jul 12;55(1):134-6.

Longitudinal change in hippocampal volume as a function of apolipoprotein E genotype.

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Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.


The epsilon4 allele of the apolipoprotein E (APOE) gene confers an increased risk for the development of AD. The authors compared longitudinal rates of change in hippocampal volume as a function of APOE genotype in nondemented elderly individuals. Rate of volumetric loss was significantly greater among epsilon4+ compared with epsilon4- individuals. These results indicate that individuals positive for the APOE epsilon4 allele may show a greater rate of hippocampal atrophy than their epsilon4- counterparts, even in the absence of a diagnosis of AD.

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