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Org Lett. 2000 Jul 13;2(14):2141-3.

A "traceless" Staudinger ligation for the chemoselective synthesis of amide bonds.

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  • 1Department of Chemistry, University of California, Berkeley, California 94720, USA.


[reaction: see text] Here we report a novel modification of our previously reported "Staudinger ligation" that generates an amide bond from an azide and a specifically functionalized phosphine. This method for the selective formation of an amide bond, which does not require the orthogonal protection of distal functional groups, should find general utility in synthetic and biological chemistry.

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