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Bioorg Med Chem Lett. 2000 Jun 19;10(12):1347-50.

Synthesis and uptake of nitric oxide-releasing drugs by the P2 nucleoside transporter in Trypanosoma equiperdum.

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  • 1Laboratoire de Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique-ESA-CNRS 5068, Université de Toulouse III, France.


A series of S-nitrosothiols, structurally related to the NO*-donor S-nitroso-N-acetylpenicillamine, and of organic nitrate esters that contain amidine groups which specify a recognition via the trypanosomal purine transporter P2, were synthesized and tested for their ability to inhibit the uptake of [2-(3)H]adenosine on Trypanosoma equiperdum.

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