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Bioorg Med Chem Lett. 2000 Jun 19;10(12):1307-10.

sp2-bridged diaryl retinoids: effects of bridge-region substitution on retinoid X receptor (RXR) selectivity.

Author information

1
Medicinal Chemistry Department, Molecular Medicine Research Institute, Mountain View, CA 94043, USA. mdawson@mmrx.org

Abstract

RXR class selectivity and RXR transcriptional activation activity compared to those for the retinoic acid receptor subtypes were enhanced on the 4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenylethenyl)be nzoic acid scaffold and its 3-methyl analogue by replacing their 1,1-ethenyl bridge by a 1,1-(2-methylpropenyl) or cyclopropylidenylmethylene group.

PMID:
10890152
[Indexed for MEDLINE]

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