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Vet Parasitol. 2000 Jul 24;91(1-2):33-42.

Vaccination of mice against schistosoma bovis with a recombinant fatty acid binding protein from Fasciola hepatica.

Author information

1
Lab. Parasitología, Facultad de Farmacia, Universidad de Salamanca, Avda Campo Charro s/n, 37007, Salamanca, Spain.

Abstract

Two strains of mice (NMRI and C57/BL) were each immunized with a 15kDa recombinant Fasciola hepatica fatty acid binding protein (FABP) (Fh15) and challenged percutaneously with Schistosoma bovis cercariae. C57/BL mice immunized with Fh15 had significant reductions in S. bovis worm burden recoveries (72% reductions over controls). When using NMRI mice, Fh15 in Freund's adjuvant failed to induce significant protection against S. bovis. In C57/BL mice, only antibodies to the IgG2a isotype increased after the second immunization and remained high through 8 weeks of S. bovis infection. This is the first time that a heterologous recombinant molecule from F. hepatica has been used in vaccination against S. bovis, obtaining a significant reduction in the number of worms in C57/BL mice.

PMID:
10889358
DOI:
10.1016/s0304-4017(00)00263-6
[Indexed for MEDLINE]

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