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Curr Opin Genet Dev. 2000 Aug;10(4):350-6.

Vertebrate mesendoderm induction and patterning.

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  • 1Department of Biochemistry, Center for Developmental Biology, University of Washington, Seattle 98195-7350, USA.


Many of the key molecular events underlying the induction and patterning of the vertebrate mesoderm and endoderm have recently been elucidated. T-box transcription factors and TGF-beta and Wnt signaling pathways play crucial roles in the initial induction of the mesendoderm and the subdivision of the posterior mesoderm into rostral and caudal domains.

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