Send to

Choose Destination
Curr Opin Genet Dev. 2000 Aug;10(4):363-9.

Notch signal transduction: a real rip and more.

Author information

Department of Biological Chemistry, UCLA School of Medicine, Los Angeles, 90095-1737, USA.


The Notch signaling pathway functions in a wide variety of processes that regulate tissue patterning and morphogenesis in developing vertebrates and invertebrates. Research on the mechanism of ligand-induced Notch signal transduction has revealed a novel and essential element in the signal cascade. Some recent findings support a model in which sequential proteolytic cleavage serves to regulate Notch signal transduction.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center