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Curr Opin Genet Dev. 2000 Aug;10(4):363-9.

Notch signal transduction: a real rip and more.

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1
Department of Biological Chemistry, UCLA School of Medicine, Los Angeles, 90095-1737, USA. gweinmaster@mednet.ucla.edu

Abstract

The Notch signaling pathway functions in a wide variety of processes that regulate tissue patterning and morphogenesis in developing vertebrates and invertebrates. Research on the mechanism of ligand-induced Notch signal transduction has revealed a novel and essential element in the signal cascade. Some recent findings support a model in which sequential proteolytic cleavage serves to regulate Notch signal transduction.

PMID:
10889061
[Indexed for MEDLINE]
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