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Curr Opin Genet Dev. 2000 Aug;10(4):393-8.

Drawing lines in the Drosophila wing: initiation of wing vein development.

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Division of Biology, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla 92093-0349, USA.


It has been proposed that wing veins in Drosophila form at boundaries between discrete sectors of cells that subdivide the anterior-posterior axis of the developing wing primordium. Recently, analysis of events underlying initiation of vein formation suggests that there is a general developmental mechanism for drawing lines between adjacent domains of cells, which is referred to as 'for-export-only-signaling'. In this model, cells in one domain produce a short range signal to which they cannot respond. As a consequence of this constraint, cells lying in a narrow line immediately outside the signal-producing domain are the only cells that can respond to the signal by activating expression of vein-promoting genes.

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