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Bioorg Med Chem Lett. 2000 Jul 3;10(13):1459-62.

Synthesis and structure-activity relationships of novel fungal chitin synthase inhibitors.

Author information

1
Department of Chemistry, Nippon Roche Research Center, Kamakura, Kanagawa, Japan.

Abstract

A novel Candida albicans chitin synthase 1 (CaChs1) inhibitor, RO-41-0986 (1) was discovered by random screening. Systematic modification led to the identification of a highly potent CaChs1 inhibitor, RO-09-3024 (2), having strong antifungal activity against Candida spp. in vitro.

PMID:
10888332
DOI:
10.1016/s0960-894x(00)00257-2
[Indexed for MEDLINE]

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