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J Interferon Cytokine Res. 2000 Jun;20(6):589-96.

Dose-dependent and schedule-dependent effects of interleukin-12 on antigen-specific CD8 responses.

Author information

1
Genetics Institute, Andover, MA 01810, USA.

Abstract

Interleukin-12 (IL-12) has been shown to play a central role in the innate and acquired immune responses. Its activities include enhancement of natural killer (NK) and cytotoxic T lymphocyte (CTL) activity and promotion of CD4 Th1 cell development. It has also been shown to provide potent activity as a vaccine adjuvant in generating antibody and T cell responses. We have investigated the efficacy of IL-12 protein in promoting CD8 T cell responses when it is used as an adjuvant for immunization. Studies using, as antigen, cDNA from an autologous antigen (P1A) as well as studies of responses to vaccinia virus-delivered self (gp100) and non-self (beta-galactosidase) antigens show that the dose and schedule of IL-12 administration can significantly affect adjuvant activity, leading to enhancement or suppression of antigen-specific responses.

PMID:
10888115
PMCID:
PMC2078235
DOI:
10.1089/10799900050044787
[Indexed for MEDLINE]
Free PMC Article

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