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J Antimicrob Chemother. 2000 Jul;46(1):91-4.

Effect of grepafloxacin on cytokine production in vitro.

Author information

1
Cellular Technology Institute, Otsuka Pharmaceutical Co. Ltd, 463-10 Kagasuno, Kawauchi-cho, Tokushima City, Japan. y_ono@research.otsuka.co.jp

Abstract

The effect of a new quinolone antibacterial agent, grepafloxacin, on the production of cytokines was investigated using lipopolysaccharide-stimulated human peripheral blood cells. Grepafloxacin 1-30 mg/L inhibited the production of interleukin 1alpha (IL-1alpha) and IL-1beta, and the expression of IL-1alpha, IL-1beta, tumour necrosis factor alpha (TNFalpha), IL-6 and IL-8 mRNA. These results suggest that the inhibitory effect of grepafloxacin is exerted, in part, at the gene transcription level.

PMID:
10882695
DOI:
10.1093/jac/46.1.91
[Indexed for MEDLINE]

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