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J Med Chem. 2000 Jun 15;43(12):2324-31.

Hydroxamic acid derivatives as potent peptide deformylase inhibitors and antibacterial agents.

Author information

1
Preclinical Research, F. Hoffmann-La Roche Ltd., CH-4070 Basle, Switzerland.

Abstract

Low-molecular-weight beta-sulfonyl- and beta-sulfinylhydroxamic acid derivatives have been synthesized and found to be potent inhibitors of Escherichia coli peptide deformylase (PDF). Most of the compounds synthesized and tested displayed antibacterial activities that cover several pathogens found in respiratory tract infections, including Chlamydia pneumoniae, Mycoplasma pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. The potential of these compounds as antibacterial agents is discussed with respect to selectivity, intracellular concentrations in bacteria, and potential for resistance development.

PMID:
10882358
DOI:
10.1021/jm000018k
[Indexed for MEDLINE]

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