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Curr Opin Lipidol. 2000 Jun;11(3):243-51.

Apolipoprotein E and atherosclerosis.

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1
The Scripps Research Institute, Department of Immunology, La Jolla, California 92037, USA. lcurtiss@scripps.edu

Abstract

Apolipoprotein E plays a key protective role in atherosclerosis. Its capacity to safeguard against this disease can be attributed to at least three distinct functions. First, plasma apolipoprotein E maintains overall plasma cholesterol homeostasis by facilitating efficient hepatic uptake of lipoprotein remnants. Second, lesion apolipoprotein E in concert with apolipoprotein A-I facilitates cellular cholesterol efflux from macrophage foam cells within the intima of the lesion. Third, lesion apolipoprotein E directly modifies both macrophage- and T lymphocyte-mediated immune responses that contribute to this chronic inflammatory disease.

PMID:
10882339
[Indexed for MEDLINE]
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