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Nat Immunol. 2000 Jul;1(1):23-9.

The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling.

Author information

1
Department of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis MO 63110, USA. dustin@immunology.wustl.edu

Abstract

The actin cytoskeleton seems to play two critical roles in the activation of T cells. One of these roles is T cell shape development and movement, including formation of the immunological synapse. The other is the formation of a scaffold for signaling components. This review focuses on the recent convergence of cell biology and immunology studies to explain the role of the actin cytoskeleton in creating the molecular basis for immunological synapse formation and T cell signaling.

PMID:
10881170
DOI:
10.1038/76877
[Indexed for MEDLINE]

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