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Neurosci Biobehav Rev. 2000 Jul;24(5):571-9.

The dual control model of male sexual response: a theoretical approach to centrally mediated erectile dysfunction.

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The Kinsey Institute for Research in Sex, Gender and Reproduction, Morrison Hall 313, Indiana University, 1165 East Third Street, Bloomington, IN 47405-3700, USA.,


A theoretical model of dual control of male sexual response is considered, based on the balancing of central excitation and inhibition, with individuals varying in their propensity for both sexual excitation and inhibition of sexual response. A questionnaire method for measuring propensities for sexual excitation and inhibition has been developed (SIS/SES questionnaire), resulting in one excitation factor (SES) and two inhibition factors (SIS1 and SIS2). Evidence for the existence of both inhibitory and excitatory tone is discussed. The first inhibition factor (SIS1) may be related to level of inhibitory tone and is associated with fear of performance failure. The second inhibition factor (SIS2) may be related to external threats (e.g. from within the sexual relationship). The implications for the treatment of centrally mediated erectile dysfunction are discussed, with predictions that high SIS2 individuals will respond to psychological treatment, whereas high SIS1 individuals will respond better to pharmacological methods of treatment.

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