Format

Send to

Choose Destination
Nat Cell Biol. 2000 Jul;2(7):E133-6.

The superfamily of heptahelical receptors.

Author information

1
Howard Hughes Medical Institute and Departments of Medicine (Cardiology) and Biochemistry, Duke University Medical centre, Durham, North Carolina 27710, USA. lefko001@receptor-biol.duke.edu

Abstract

Despite a growing appreciation of functional analogies between visual and hormonal signalling systems in the early 1980s, the discovery of the close structural relationship between rhodopsin and the beta2-adrenergic receptor, and of the existence of a larger 'superfamily' of such receptors, came as a total surprise. Here I provide a personal perspective on events leading up to and flowing from this exciting discovery that opened up a vast field of research.

PMID:
10878827
DOI:
10.1038/35017152
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center