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Nat Cell Biol. 2000 Jul;2(7):435-40.

Modulation of retinoid signalling through NGF-induced nuclear export of NGFI-B.

Author information

1
Section on Growth Factors, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA. katagiriy@usa.redcross.org

Abstract

The retinoid-X receptor (RXR) regulates multiple hormonal pathways through heterodimerization with nuclear receptors such as the all-trans retinoic acid receptor (RAR). The orphan nuclear receptor NGFI-B (also called Nur77) can heterodimerize with RXR. Here we show that nerve growth factor (NGF) induces the phosphorylation of Ser 105 of NGFI-B in PC12 phaeochromocytoma cells, resulting in translocation of the NGFI-B-RXR heterodimer complex out of the nucleus using nuclear export signals within NGFI-B. As a consequence of the redistribution of RXR, the transcriptional activity of RXR-RAR is reduced. NGFI-B-mediated nuclear export of receptors may serve as a mechanism for crosstalk between NGF and retinoid pathways.

PMID:
10878809
DOI:
10.1038/35017072
[Indexed for MEDLINE]

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