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FEBS Lett. 2000 Jun 30;476(1-2):58-61.

AKAP79 and the evolution of the AKAP model.

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Howard Hughes Medical Institute, Vollum Institute, 3181 S.W. Sam Jackson Park Road, 97201-3098, Portland, OR, USA.


A molecular explanation for the specificity of the cAMP-dependent protein kinase (PKA) can be provided by its compartmentalization through association with A-kinase-anchoring proteins (AKAPs). Structural and functional studies have led to the development of an anchoring model proposing that AKAPs contain a common PKA binding domain and a unique subcellular targeting domain. The discovery that AKAPs can bind other signaling enzymes led to the addition of a third property, that of scaffolding molecule. Recent research has now expanded the role of AKAPs to members of multiunit complexes containing both upstream activators and downstream targets.

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