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Ann Intern Med. 2000 Jul 4;133(1):35-9.

3-year suppression of HIV viremia with indinavir, zidovudine, and lamivudine.

Author information

1
Weill Medical College of Cornell University, New York, New York, USA. rgulick@med.cornell.edu

Abstract

BACKGROUND:

Antiretroviral regimens containing HIV protease inhibitors suppress viremia in HIV-infected patients, but the durability of this effect is not known.

OBJECTIVE:

To describe the 3-year follow-up of patients randomly assigned to receive indinavir, zidovudine, and lamivudine in an ongoing clinical trial.

DESIGN:

Open-label extension of a randomized, double-blind study.

SETTING:

Four clinical research units.

PATIENTS:

33 HIV-infected, zidovudine-experienced patients with serum HIV RNA levels of at least 20,000 copies/mL and CD4 counts ranging from 50 to 400 cells/mm3.

INTERVENTION:

Indinavir, zidovudine, and lamivudine.

MEASUREMENTS:

Safety assessments, HIV RNA levels, CD4 cell counts, and genotypic analyses.

RESULTS:

After 3 years of follow-up, 21 of 31 contributing patients (68% [95% CI, 49% to 83%]) had serum viral load levels less than 500 copies/mL. Twenty of 31 (65% [CI, 45% to 80%]) had levels less than 50 copies/mL. The median increase in CD4 count from baseline was 230 cells/mm3 (interquartile range, 150 to 316 cells/mm3). Nephrolithiasis occurred in 12 of 33 patients (36%).

CONCLUSION:

A three-drug regimen of indinavir, zidovudine, and lamivudine suppressed viremia in two thirds of patients for at least 3 years.

PMID:
10877738
[Indexed for MEDLINE]

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