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Curr Opin Cell Biol. 2000 Aug;12(4):420-30.

Multiple pathways allow protein secretion across the bacterial outer membrane.

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Department of Molecular Genetics and Microbiology, 130 Life Sciences Building, Center for Infectious Diseases, State University of New York at Stony Brook, Stony Brook, 11794-5222, USA.


Secretion of proteins across the bacterial outer membrane takes place via a variety of mechanisms from simple one-component systems to complex multicomponent pathways. Secretion pathways can be organized into evolutionarily and functionally related groups, which highlight their relationship with organelle biogenesis. Recent work is beginning to reveal the structure and function of various secretion components and the molecular mechanisms of secretion.

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