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Curr Opin Cell Biol. 2000 Aug;12(4):503-8.

Connecting vesicle transport to the cytoskeleton.

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Department of Cellular and Molecular Medicine, Department of Pharmacology, Howard Hughes Medical Institute, School of Medicine, University of California San Diego, La Jolla, 92093-0683, USA.


The cytoskeleton is crucial for the efficient and polarized transport of vesicles in intracellular membrane-sorting pathways. Recent studies have identified specific kinesin, dynein, and myosin motor proteins that mediate defined membrane transport steps. Important clues have also been uncovered about the nature of motor-protein receptors on vesicular cargoes and the molecular mechanisms of motor-protein regulation.

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