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Biochem Biophys Res Commun. 2000 Jun 24;273(1):5-9.

Activation of NADPH oxidase in Alzheimer's disease brains.

Author information

1
Department of Neurology, Kyoto University, Kyoto, 606-8507, Japan.

Abstract

The present study is the first to show that superoxide (O(-)(2)) forming NADPH oxidase is activated in Alzheimer's disease (AD) brains by demonstrating the marked translocation of the cytosolic factors p47-phox and p67-phox to the membrane. In conjunction with a recent in vitro study showing that amyloid beta activates O(-)(2) forming NADPH oxidase in microglia, where these phox proteins are localized in this study, the present results suggest that, in AD, NADPH oxidase is activated in microglia, resulting in the formation of reactive oxygen species which can be toxic to neighboring neurons in AD.

PMID:
10873554
DOI:
10.1006/bbrc.2000.2897
[Indexed for MEDLINE]

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