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Arch Dis Child Fetal Neonatal Ed. 2000 Jul;83(1):F39-43.

Metabolic and respiratory effects of theophylline in the preterm infant.

Author information

1
Dipartimento di Pediatria, Via Giustiniani 3, 35128 Padova, Italy. carnielli@child.pedi.unipd.it

Abstract

BACKGROUND:

Methylxanthines are often administered to preterm infants for the treatment of apnoea.

AIMS:

To study the effects of theophylline on energy metabolism, physical activity, and lung mechanics in preterm infants.

METHODS:

Indirect calorimetry was performed for six hours before and after administration of a bolus of theophylline (5 mg/kg) in 18 preterm infants while physical activity was recorded with a video camera. Lung mechanics measurements were performed at baseline and 12 and 24 hours after theophylline treatment.

RESULTS:

Theophylline increased mean (SEM) energy expenditure by 15 (5) kJ/kg/day and augmented carbohydrate utilisation from 6.8 to 8.0 g/kg/day, but fat oxidation was unchanged. After theophylline treatment, preterm infants had faster respiration, lower transcutaneous CO2, and improved static respiratory compliance without increased physical activity.

CONCLUSIONS:

A bolus of 5 mg/kg theophylline increased energy expenditure independently of physical activity, increased carbohydrate utilisation, and improved respiratory compliance. The increased energy expenditure could be detrimental to the growth of the preterm infant.

PMID:
10873170
PMCID:
PMC1721103
[Indexed for MEDLINE]
Free PMC Article

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