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Immunol Today. 2000 Jul;21(7):337-42.

IFN-alpha and IFN-beta: a link between immune memory and chronic inflammation.

Author information

1
Department of Clinical Immunology, Royal Free and University College Medical School, Hampstead, London, UK. akbar@rfhsm.ac.uk

Abstract

The majority of expanded T cells generated during an immune response are cleared by apoptosis. Prevention of death in some activated T cells enables the persistence of a memory T-cell pool. Here, observations that IFN-alpha and IFN-beta inhibit activated T-cell apoptosis are described. Although this enables memory T cells to persist without antigen, excessive IFN-alpha or IFN-gamma secretion might lead to chronic inflammation.

PMID:
10871875
DOI:
10.1016/s0167-5699(00)01652-2
[Indexed for MEDLINE]

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