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FEMS Microbiol Lett. 2000 Jul 1;188(1):103-6.

The role of the bacitracin ABC transporter in bacitracin resistance and collateral detergent sensitivity.

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1
Department of Biology, University of Ljubljana, Slovenia. zdravko.podlesek@uni-lj.si

Abstract

The bacitracin resistance of Bacillus licheniformis, a producer of bacitracin, is mediated by the ABC transporter Bcr. Bacillus subtilis cells carrying bcr genes on high-copy number plasmids developed collateral detergent sensitivity, as did human cells with overexpressed multidrug resistance P-glycoprotein. Resistance against bacitracin and sensitivity of resistant cells to detergents were shown to be inseparable phenomena associated with the membrane part of Bcr transporter, namely protein BcrC. A fused protein, consisting of ATP-binding protein BcrA and membrane component BcrC was constructed. It resembled a half molecule of P-glycoprotein and was capable of providing a significant degree of antibiotic resistance and detergent sensitivity.

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