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Bioorg Med Chem Lett. 2000 Jun 5;10(11):1303-6.

Synthesis and evaluation of geldanamycin-testosterone hybrids.

Author information

1
Departement of Medicine, Sloan-Kettering Institute for Cancer Research, New York, NY 10021, USA.

Abstract

Geldanamycin (GDM) binds to the Hsp90 chaperone protein resulting in the degradation of several important signaling proteins. A series of GDM-testosterone linked hybrids has been synthesized and evaluated for activity against prostate cancer cell lines. The hybrid with the greatest activity exhibits potent and selective cytotoxicity against prostate cancer cells containing the androgen receptor.

PMID:
10866406
DOI:
10.1016/s0960-894x(00)00208-0
[Indexed for MEDLINE]

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