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Bioorg Med Chem Lett. 2000 Jun 5;10(11):1185-8.

Beta-casomorphins: substitution of phenylalanine with beta-homo phenylalanine increases the mu-type opioid receptor affinity.

Author information

1
Dipartinento di Scienza degli Alimenti, Università di Napoli Federico II, Portici, Italy. luilongo@unina.it

Abstract

Two analogues of bovine beta-casomorphin-7 and beta-casomorphin-5 containing a beta-homo phenylalanine in substitution of the phenylalanine in position 3 were synthesised and tested for their mu-opioid receptor affinity. The modification enhanced the mu receptor affinity 5-fold in the case of modified beta-CM-7 and 2-fold for modified beta-CM-5 when compared to the natural peptides.

PMID:
10866377
DOI:
10.1016/s0960-894x(00)00187-6
[Indexed for MEDLINE]

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