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Res Microbiol. 2000 Mar;151(2):91-5.

Evolution-driving genes.

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Faculté de médecine Necker-Enfants malades, Inserm E9916, université Paris-V, France.


Genomic sequences provide evidence for a common origin of life and its evolution via selection of genetic variants created by mutation and recombination. Two classes of genes are known to accelerate mutation and/or recombination rates in bacterial populations: stress-inducible wild-type genes, usually part of the SOS regulon, and genes whose functional loss, or downregulation, increases the rate of genetic variability (mutator and/or hyper-rec mutants).

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