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Ann N Y Acad Sci. 2000 May;902:272-81; discussion 281-2.

The fat mouse. A powerful genetic model to study hemostatic gene expression in obesity/NIDDM.

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Department of Vascular Biology, Scripps Research Institute, La Jolla, California 92037, USA.


In this chapter, we summarize our studies on plasminogen activator inhibitor 1 (PAI-1), tissue factor, and transforming growth factor beta (TGF-beta) expression in obesity, using genetically obese mice as a model. These studies emphasize the key role played by the adipocyte, a cell whose numbers, size, and metabolic activity are grossly altered in obesity/NIDDM. They also implicate multiple cytokines, hormones, and growth factors in the abnormal expression of these and perhaps other hemostatic genes by adipocytes in obesity/NIDDM. These studies demonstrate that tumor necrosis factor alpha (TNF-alpha) plays a central role in the expression of hemostatic genes in this disorder.

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