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Int Arch Allergy Immunol. 2000 May;122(1):1-7.

Antigen recognition by human gammadelta T lymphocytes.

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1
Institute of Immunology, University of Kiel, Kiel, Germany. kabelitz@immunologie.uni-kiel.de

Abstract

Mature T lymphocytes carrying the conventional alphabeta T cell receptor (TCR) recognize peptide antigens in the context of MHC class I (CD8+) and MHC class II (CD4+) antigens, respectively. In striking contrast, human gammadelta T lymphocytes recognize unconventional antigens via their heterodimeric TCR in a non-MHC-restricted fashion. In this brief review, we discuss recent progress in the identification of ligands that are specifically recognized by human gammadelta T cells. It appears that gammadelta T cells have evolved to supplement the cellular immune response towards antigens that are not seen by alphabeta T lymphocytes.

PMID:
10859464
DOI:
10.1159/000024353
[Indexed for MEDLINE]
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