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Trends Neurosci. 2000 Jul;23(7):298-304.

Energetics in the pathogenesis of neurodegenerative diseases.

Author information

1
Dept of Neurology and Neuroscience, Weill Medical College of Cornell University and the New York Hospital, Weill Cornell Medical Center, New York, NY 10021, USA.

Abstract

Mitochondria have been linked to both necrotic and apoptotic cell death, which are thought to have a major role in the pathogenesis of neurodegenerative diseases. Recent evidence shows that nuclear gene defects affecting mitochondrial function have a role in the pathogenesis of Friedreich's ataxia, Wilson's disease and hereditary spastic paraplegia. There is also accumulating evidence that mitochondrial dysfunction might have a role in the pathogenesis of amyotrophic lateral sclerosis, Huntington's disease, Parkinson's disease and Alzheimer's disease. If this is so, a number of therapeutic targets are implicated that might result in novel treatments for neurodegenerative diseases.

PMID:
10856939
DOI:
10.1016/s0166-2236(00)01584-8
[Indexed for MEDLINE]

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