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Trends Cell Biol. 2000 Jul;10(7):261-7.

Spindle assembly and the art of regulating microtubule dynamics by MAPs and Stathmin/Op18.

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Dept of Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0357, USA.


The way that microtubules reorganize from their long, stable interphase configuration to form the mitotic spindle remains a challenging and unsolved question. It is now widely recognized that microtubule polymerization during the cell cycle is regulated by a balance between microtubule-stabilizing and-destabilizing factors. Stabilizing factors include a large group of microtubule-associated proteins (MAPs; e.g. MAP4, XMAP215, XMAP230/XMAP4 and XMAP310) and the destabilizing factors are a growing family of proteins (e.g. Stathmin/Op18 and XKCM1). Recent studies have allowed a mechanistic dissection of how these stabilizing and destabilizing factors regulate microtubule dynamics and spindle assembly.

[Indexed for MEDLINE]

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