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Trends Endocrinol Metab. 2000 Jul;11(5):163-8.

Functional significance of oligomerization of G-protein-coupled receptors.

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Department of Biochemistry and Groupe de Recherche sur le Système Nerveux Autonome, Université de Montréal, Québec, Canada.


In contrast to other families of cell surface receptors for which dimerization is an integral part of the activation process, G-protein-coupled receptors (GPCRs) were thought, until recently, to function as monomeric units. However, a growing body of evidence indicates that GPCRs could exist and be active as oligomeric complexes. Because they are major pharmacological targets, their existence as homo- or heterodimers could have important implications for the development and screening of new drugs.

[Indexed for MEDLINE]

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