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Vaccine. 2000 Jul 15;18(27):3077-81.

Identification of T-helper cell epitopes in the hypervariable region of the nucleocapsid (N) protein of rinderpest virus (RPV) in cattle.

Author information

1
Institute for Animal Health, Pirbright Laboratory, Ash Road, Surrey, GU24 0NF, Woking, UK.

Abstract

The proliferative responses to synthetic peptides by lymphocytes derived from rinderpest virus (RPV)-infected cattle, the natural host for RPV, were assayed by determining [3H]thymidine incorporation into the DNA. In eight out of twelve cattle tested, significant responses were detected to peptides representing amino acids 452-501 in the C-terminal hypervariable region of the virus nucleocapsid (N) protein. It appears that helper T-cell epitope(s) for cattle which can be broadly recognized within an MHC diverse population, exists in this region of the protein.

PMID:
10856786
DOI:
10.1016/s0264-410x(99)00538-1
[Indexed for MEDLINE]

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